8 kommentarer

  1. Good job Pal!!!! You should boast… VERY HAAAAWT STUDY. Dr. Briffa and Chris at ConditionResearch.com just talked about it…

    I like the graph with indiv data points showing responders v. non-responders. I wish somehow hormone profile were taken: leptin, cortisol (am v. pm), E1 E2 E3, P, DHEA, T free-T, FT4 FT3 rT3, insulin, post-prandial insulin, insulin clamp, etc. Is that asking too much?

    Why do you think some failed to build more lean mass despite adequate amino acids, stimulus and insulin/IGF?


  2. Thanks

    It's an exiting field to study.
    I thought it was important to include individual data, when the variations were that big and the study so small.
    Believe me, I would have tested for a whole lot of hormones if I had more funding.
    I do suspect that a larger intervention would have revealed a correlation between low protein intake and lack of LBM maintenance. At an individual level it is not certain that there were adequate amino acids.


  3. Any idea what the energy levels were like in the LC group? I know there is often criticism that those who follow a LC diet become more economical in their movement, often maintaining structured exercise, but become more economical in other facets of life (I personally haven't found this myself – in fact the exact opposite).


  4. We could not see any observable difference in the ability to exercise at the requested resistance and we did not measure energy expenditure in this study. It would have been really interesting to also have a good measure of expenditure. There is the whole deal with metabolic advantage (check out Dr. Eades and Colpo's blogging battle). There is a need for a well controlled macronutrient study with accurate measures of energy intake and expenditure, including exercise energy expenditure.


  5. Perhaps in any follow up study, a journal or survey of subjective measures could be used. Yes, subjectivity is frowned upon in science, but in the real world, it can be a useful tool. Wouldn't require too much additional funding either!

    I think Colpo might be making a song about nothing. Eades et al who have theorised a metabolic advantage also admit it is relatively small in the grand scheme of things… plenty of other health advantages to be had from LC eating aside from a very slight thermogenic advantage.

    Regarding economy of movement, my own experience and observation of others has been that those who reduce carbohydrate without simultaneously increasing fat intake (e.g. body builders) find energy levels falling progressively over time. Those who decrease carbohydrate and increase fat seem to maintain, if not increase energy levels once fully adapted over to increased fat metabolism. It would be nice to have this sort of information formalised though – may help silence a few doubters!

    Great blog by the way – really awesome explanations. You have a fan in New Zealand!


  6. Thank you Jamie.
    I agree the cutting both fat and carbs is not optimal for energy. Stephen D. Phinney described the condition «rabbit malaise» the inuit people got when eating lean rabbits with to little fat on them. The physiology here is basic. If you cut carbs, fat is your main energy substrate, but your fat tissue can not support a high metabolism alone. You also need fat from food.


  7. Pål,

    Organ meats? I've read about leucine and mTOR and taurine — just like B-vitamins during stress, perhaps, certain amino acids are depleted during weight gain and/or have higher requirements during shifting energy balance? Evolutionwise, after a kill or fishing, leucine and taurine would be available abundantly from organ meats (heart, lung)… (fresh, not all cooked).



  8. Yes, these are factors that might in part explain individual differences in lean body mass. Leucine may increase mTOR phosphorylation and increase protein synthesis. How the requirements of different amino acids might shift with differences in metabolism, is something I'm going to have to look into.


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