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The carnivore connection hypothesis
I just came across this article [1] and found that it’s really quite interesting. It’s about why we are insulin resistant. Even though the term «insulin resistance» is mostly used to describe a pathological condition, all tissues that can respond to insulin are, to some extent, insulin resistant and so we are all displaying various…
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Low fat – another nail in the coffin
So here’s an interesting study: «Effects of a lifestyle intervention in metabolically benign and malign obesity.« From the intro: “In the last few years it has been shown that metabolically healthy obese (MHO) individuals comprise roughly 30% of obese people and 10% of the adult general population [1– 5]. In addition to having insulin sensitivity…
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Macronutrients and food reward
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If you see one bright red swan, you are not likely to give up a theory that says that all swans are white; you will instead go looking for the person who painted it. Imre Lakatos Much is being said on this subject. Bet many are getting pretty fed up by now. But I still…
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The causality of insulin resistance
There seem to be two large somewhat competing hypotheses trying to explain the causality of insulin resistance (as measured at a whole body level). The lipotoxicity hypothesis, explains to us how insulin sensitivity is reduced in tissues when too much fat builds up in the specific tissue cells; likely caused by high serum levels of…
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The trouble with insulin resistance, part III
I was in way over my head starting to ramble on about insulin resistance hoping I would identify a causal link. But I feel I should finish what I’ve started. The trouble with insulin resistance is that it is so bloody hard to point to the exact cause at a cellular and molecular level. I’ve…
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More trouble with insulin resistance
I’ll make an attempt to sum up some of my previous rambling. When we talk about insulin resistance it is often important to include information on which tissues we are talking about. When insulin resistance is measured by clamp technique we are mostly measuring the hepatic insulin response. The fact that insulin resistance is mostly…
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The trouble with insulin resistance
Been thinking a lot about insulin resistance lately. Most importantly how a resistance in different tissues might cause different pathologies. Gary Taubes must have been thinking a lot about insulin resistance as well. Way more than me anyway. The following is largely based on his article in Science Magazine July 2009. It is better…
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