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Carbs and cancer
This is not one of those “carbs cause cancer” posts. I though “Carbs and cancer” had a better ring to it than for example “Metabolism and cancer”, what with the alliteration and all. Still, it’s important to remember that although carbohydrate restriction is an effective treatment for cancer, this does not mean cancer is caused…
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Macronutrients and food reward
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If you see one bright red swan, you are not likely to give up a theory that says that all swans are white; you will instead go looking for the person who painted it. Imre Lakatos Much is being said on this subject. Bet many are getting pretty fed up by now. But I still…
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The causality of insulin resistance
There seem to be two large somewhat competing hypotheses trying to explain the causality of insulin resistance (as measured at a whole body level). The lipotoxicity hypothesis, explains to us how insulin sensitivity is reduced in tissues when too much fat builds up in the specific tissue cells; likely caused by high serum levels of…
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Just a small reminder
”…low carbohydrate diet sets the stage for a significant loss of lean tissue as the body recruits amino acids from muscle to maintain blood glucose via gluconeogenesis.” Exercise Physiology, Mcardle, Katch & Katch 2007 There is one aspect of human metabolism that is too often…
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Cancer as a metabolic disease
Is cancer a metabolic disease? In principle, there are few chronic diseases more easily preventable than cancer. Seyfried and Shelton 2010 A new and important article in Nutrition and Metabolism makes a case for cancer as predominately a metabolic disease. Research has shown that one of the key features of cancers is an impaired or…
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A scale model of obesity
Whatever the individual cause of obesity is, in the absolute majority of cases, carbohydrate restriction works effectively at reducing adipose tissue weight. This is a common observation in most human and animal studies. Carbohydrate restriction for the most part works because it influences insulin and glucose. In addition it affects our sensations of hunger and…
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Does it fit the facts?
Explaining overweight through the effect of insulin and glucose metabolism on fat tissue can so far only be termed a hypothesis. It is a hypothesis build primarily on physiological knowledge. The next logical step is to check if the hypothesis fits the observations that have been done and if it can adequately explain these observations.…
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The second question provides the answer
On our way to understand overweight we have (that is I have, but I thought you should be included) defined overweight as excess storage of energy in fat tissue and we asked the obvious; what factors control the storage of energy in fat tissue? The answer is glucose (a simple sugar that when it’s in…
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The important question
By defining overweight as excess storage of energy in fat tissue (and consequently to little use of energy from the same tissue), we are only one simple question away from understanding what causes overweight and obesity, and ultimately how to treat and prevent it. What factors control storage and release of energy in fat tissue?…
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