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Food reward, a factor in obesity
“I think food reward offers the most compelling explanation for the US/global obesity epidemic.” Stephan Guynet “In studies where the food intake and energy expenditure of subjects are carefully monitored over a period of weeks to months (which tends to average out day-to-day fluctuations) a remarkable balance between calories consumed and calories burned was observed.…
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Fat people are liars
Obviously! Obesity is a remarkably simple problem to solve. Eat less and move more. When energy expenditure exceeds energy intake, you lose weight. Many people claim to have tried eating less and exercising more and claim that it does not work. As this would be a violation of the laws of thermodynamics it is quite…
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You want cognitive dissonance? I’ll give you cognitive dissonance!
The latest issue of Obesity offers both welcome rationality, important discussions and good chances of some decent hair pulling. It features an editorial by Jean-Pierre Flatt from the Department of Biochemistry and Molecular Biology, University of Massachusetts. Flatt gives us an insight into some important misconceptions about obesity. He even made us a list of…
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Leptin and local cellular hunger – uniting the theories
Leptin About 15 years ago the 167 amino acid peptide hormone leptin was discovered by Jeffrey M. Friedman and colleagues through work with genetic mouse models. It is primarily expressed in adipose tissue and there is thus a close correlation between the blood level of leptin and the size of the fat tissue. A small fat…
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Local cellular hunger
I once wrote a short paper about menstrual disturbances in female athletes. Menstrual disorders seem to be more prevalent in athletes than sedentary controls and more prevalent in sports emphasizing leanness. Elite athletes also have higher menarche age compared to non elite athlete controls. Menstrual disorders increase the risk of low bone mineral density, stress…
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A scale model of obesity
Whatever the individual cause of obesity is, in the absolute majority of cases, carbohydrate restriction works effectively at reducing adipose tissue weight. This is a common observation in most human and animal studies. Carbohydrate restriction for the most part works because it influences insulin and glucose. In addition it affects our sensations of hunger and…
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The important question
By defining overweight as excess storage of energy in fat tissue (and consequently to little use of energy from the same tissue), we are only one simple question away from understanding what causes overweight and obesity, and ultimately how to treat and prevent it. What factors control storage and release of energy in fat tissue?…
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Defining overweight
The first thing I’m going to do in this blog is to explain what causes overweight and obesity. I’ll also explain what can be done about it. It will not be the old dogma of eating less and exercising more. It will be the truth this time. None of the theories described here are my…