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The folly of the mean – Why do they differ so?
A few years ago I did a small study where we combined a ketogenic diet with resistance exercise [1]. After 10 weeks the 8 women in the diet group experienced a mean weight loss of 5,6kg. DEXA-scanning (Dual Energy X-ray Absorptiometry) showed that the mean fat mass loss was 5,6kg and that the fat free…
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Overfeeding – Calories count, but don’t bother counting them
«The upper two sets of figures show Mr. A. Levanzin of Malta, Dr. Benedict’s celebrated subject, before and at the completion of his fast. ‘About two and a half years ago, while I was over-eating, obese, neurasthenic, pessimistic and with a shattered nervous system, I chanced to read. . . an article about fasting. It…
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Fat people are liars
Obviously! Obesity is a remarkably simple problem to solve. Eat less and move more. When energy expenditure exceeds energy intake, you lose weight. Many people claim to have tried eating less and exercising more and claim that it does not work. As this would be a violation of the laws of thermodynamics it is quite…
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A closer look at adiponectin
Whether insulin or leptin or adiponectin or PPAR gamma or NF KB or a bajillion cytokines are the proximate mediators of obesity or atherosclerosis is hardly the point, is it? Kurt G. Harris MD Although biochemistry can be marvelously exiting we must not lose sight of the bigger picture. It is increasingly unlikely that any…
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Leptin and local cellular hunger – uniting the theories
Leptin About 15 years ago the 167 amino acid peptide hormone leptin was discovered by Jeffrey M. Friedman and colleagues through work with genetic mouse models. It is primarily expressed in adipose tissue and there is thus a close correlation between the blood level of leptin and the size of the fat tissue. A small fat…
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Local cellular hunger
I once wrote a short paper about menstrual disturbances in female athletes. Menstrual disorders seem to be more prevalent in athletes than sedentary controls and more prevalent in sports emphasizing leanness. Elite athletes also have higher menarche age compared to non elite athlete controls. Menstrual disorders increase the risk of low bone mineral density, stress…
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A scale model of obesity
Whatever the individual cause of obesity is, in the absolute majority of cases, carbohydrate restriction works effectively at reducing adipose tissue weight. This is a common observation in most human and animal studies. Carbohydrate restriction for the most part works because it influences insulin and glucose. In addition it affects our sensations of hunger and…
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Does it fit the facts?
Explaining overweight through the effect of insulin and glucose metabolism on fat tissue can so far only be termed a hypothesis. It is a hypothesis build primarily on physiological knowledge. The next logical step is to check if the hypothesis fits the observations that have been done and if it can adequately explain these observations.…
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The important question
By defining overweight as excess storage of energy in fat tissue (and consequently to little use of energy from the same tissue), we are only one simple question away from understanding what causes overweight and obesity, and ultimately how to treat and prevent it. What factors control storage and release of energy in fat tissue?…
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Defining overweight
The first thing I’m going to do in this blog is to explain what causes overweight and obesity. I’ll also explain what can be done about it. It will not be the old dogma of eating less and exercising more. It will be the truth this time. None of the theories described here are my…
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