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Colpo, Eades and black swans.
There is a blogging battle going on. Dueling, are Anthony Colpo and Michael Eades. It seems Eades has Colpo cornered, and in the last round Eades pulled the «Popper’s black swan» card. Inspired the aged but beautiful writings of Popper, I thought of some other nice quotes fitting for the nutrition debate. Enjoy! Here are some from…
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The trouble with insulin resistance, part III
I was in way over my head starting to ramble on about insulin resistance hoping I would identify a causal link. But I feel I should finish what I’ve started. The trouble with insulin resistance is that it is so bloody hard to point to the exact cause at a cellular and molecular level. I’ve…
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Ketogenic diet and resistance exercise
Not to brag, but new study out here.Hope someone will find it interesting.
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More trouble with insulin resistance
I’ll make an attempt to sum up some of my previous rambling. When we talk about insulin resistance it is often important to include information on which tissues we are talking about. When insulin resistance is measured by clamp technique we are mostly measuring the hepatic insulin response. The fact that insulin resistance is mostly…
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Just a small reminder
”…low carbohydrate diet sets the stage for a significant loss of lean tissue as the body recruits amino acids from muscle to maintain blood glucose via gluconeogenesis.” Exercise Physiology, Mcardle, Katch & Katch 2007 There is one aspect of human metabolism that is too often…
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By the way…
New exiting study in Diabetes Care. Abstract here. It seems that if you put overweight people on a resistance exercise program three days a week for 16 weeks, they will lose about two kilos of muscle mass, if they are also cutting calories. Dietary protein content doesn’t seem to influence this much. I wonder what…
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The trouble with insulin resistance
Been thinking a lot about insulin resistance lately. Most importantly how a resistance in different tissues might cause different pathologies. Gary Taubes must have been thinking a lot about insulin resistance as well. Way more than me anyway. The following is largely based on his article in Science Magazine July 2009. It is better…
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Big fat lies
Hanna Sutter from Big Fat Lies in Daily Mail: «For the past 30 years we’ve been told to eat less and exercise more, to cut back on calories and on saturated fat and, on the whole, we’re doing it. Our calorific intake between the years 1974 and 2004 decreased by 20 per cent. We are…
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Cancer as a metabolic disease
Is cancer a metabolic disease? In principle, there are few chronic diseases more easily preventable than cancer. Seyfried and Shelton 2010 A new and important article in Nutrition and Metabolism makes a case for cancer as predominately a metabolic disease. Research has shown that one of the key features of cancers is an impaired or…
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It’s your choice
A recent study by Yancy et al shows that going on a low fat calorie restricted diet in combination with the shady orlistat drug results in the same weight loss as a low carbohydrate diet over a 48 week period. In other words, go on a low fat hunger inducing diet with no scientific merit…
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Great blog and great former blogger current twitterer
Dave Dixon here:http://twitter.com/sparkofreasonand Petro Dobromylskyj here:http://high-fat-nutrition.blogspot.com/
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The tide is turning
Ronald M Krauss, former Senior Advisor to the National Cholesterol Education Program, actively involved with the American Heart Association, former Chairman of the Nutrition Committee, has in collaboration with Siri-Tarino Patty, Sun Qi and B. H. Frank conducted meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Although I have yet to read the…
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The devil is in the details
Sherlock Holmes is back on the screen. A master of deduction and a firm believer in science, he is showing us the devil is in the details. But even data acquired through vigorous scientific studies need to be exposed to the same meticulous scrutiny worthy of Holmes. For the devil does seem to reside comfortably…
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Local cellular hunger
I once wrote a short paper about menstrual disturbances in female athletes. Menstrual disorders seem to be more prevalent in athletes than sedentary controls and more prevalent in sports emphasizing leanness. Elite athletes also have higher menarche age compared to non elite athlete controls. Menstrual disorders increase the risk of low bone mineral density, stress…
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About hunger
Much has been said about hunger. The sensation is often considered largely under cognitive control. An overweight person seeking counselling is asked to eat less, despite claiming to already be hungry most of the time. Hunger is in this case simply considered by the treating authority to be suppressed by a strong will of mind.…
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A scale model of obesity
Whatever the individual cause of obesity is, in the absolute majority of cases, carbohydrate restriction works effectively at reducing adipose tissue weight. This is a common observation in most human and animal studies. Carbohydrate restriction for the most part works because it influences insulin and glucose. In addition it affects our sensations of hunger and…
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Does it fit the facts?
Explaining overweight through the effect of insulin and glucose metabolism on fat tissue can so far only be termed a hypothesis. It is a hypothesis build primarily on physiological knowledge. The next logical step is to check if the hypothesis fits the observations that have been done and if it can adequately explain these observations.…
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The second question provides the answer
On our way to understand overweight we have (that is I have, but I thought you should be included) defined overweight as excess storage of energy in fat tissue and we asked the obvious; what factors control the storage of energy in fat tissue? The answer is glucose (a simple sugar that when it’s in…
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The important question
By defining overweight as excess storage of energy in fat tissue (and consequently to little use of energy from the same tissue), we are only one simple question away from understanding what causes overweight and obesity, and ultimately how to treat and prevent it. What factors control storage and release of energy in fat tissue?…
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Defining overweight
The first thing I’m going to do in this blog is to explain what causes overweight and obesity. I’ll also explain what can be done about it. It will not be the old dogma of eating less and exercising more. It will be the truth this time. None of the theories described here are my…
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